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Insulin-like growth factor 1 (IGF-1) is a pluripotent growth factor with multiple functions in the peripheral and central nervous system

To view a copy of this licence, visit About this article Cite this article Xiang, F., Zhang, Z., Xie, J

Unlike acute wounds, which follow a well-defined healing cascade of re-epithelialization, fibroblast proliferation, and angiogenesis, chronic wounds remain trapped in a prolonged inflammatory phase characterized by microbial persistence and dysregulated immune responses [4,5,6]