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Besides, D1R-mediated cAMP/PKA/DARPP-32 signaling, Ca2+ pathway, and tyrosine phosphorylation of NR2B subunit allow for the activation of NMDA-mediated ERK, a signal integrator for dopamine and glutamate neurotransmission (73)

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Warning signs of sleep problems in Rett syndrome can include: bedtime struggles: Having problems settling down or resisting the transition to sleep at night daytime fatigue: Needing more naps than usual or appearing excessively sleepy throughout the day nighttime disruptions: Regularly waking up at night and having difficulty falling back to sleep irregular schedules: Sleeping significantly more or less than expected or following an unpredictable sleep-wake cycle noisy breathing: Snoring or gasping during the night, which may indicate airway issues Caregivers can track these changes using a screening tool called BEARS, which evaluates sleep habits based on the childs age