2017-CA-001766 (Fritz Gray, Maney & Gordon, P.A.)
Dulaglutide was less studied but showed promising signs in animals, increasing beneficial bacteria like Bacteroides, Akkermansia, and Ruminococcus
34,35,37,38 Other incretin therapies, such as activation of the gastric inhibitory polypeptide receptor (GIPR), have not been thoroughly studied in the kidney, consistent with a lack of detectable kidney GIPR expression 39
When the Breakthrough Obesity G-Agonist Drugs Exceed Expectations The expanding GLP-1 family of drugs and their expanded potential use cases Back last December I wrote about the The New Obesity Breakthrough Drugs, and specifically the striking results in randomized trials for semaglutide (Wegovy) and tirzepatide (Mounjaro) for weight loss, their putative mechanism(s), while also emphasizing their very high cost, lack of plan for successful weaning, and exacerbation of health inequities