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Advertisement Supported by Users of New Weight Loss Drug Had Lower Blood Pressure in Study The patients used tirzepatide, sold as Mounjaro or Zepbound, but researchers could not distinguish the effect of the drug from the effects of weight loss

All six doses are available: 2.5 mg ($299), 5 mg ($399), 7.5 mg ($499), 10 mg ($699), 12.5 mg ($699), and 15 mg ($699) per month

Clinical studies indicate that tirzepatide can reduce the bioavailability of oral hormonal contraceptives by around 20%

Best For Patients who have plateaued on semaglutide or tirzepatide Patients with significant weight to lose (50+ pounds) Patients with fatty liver disease (MASLD/NAFLD) or metabolic syndrome Patients who want access to the most advanced mechanism currently available Patients with established GLP-1 experience and good tolerance Side Effect Comparison All three medications share a similar side effect profile driven primarily by gastrointestinal effects: Common Side Effects (All Three) Nausea most common during dose escalation, usually resolves within 2 to 4 weeks at each dose level Diarrhea reported by 15 to 25 percent of patients Vomiting reported by 8 to 15 percent Constipation reported by 6 to 12 percent Decreased appetite nearly universal and considered therapeutic Tirzepatide and retatrutide may have slightly higher rates of GI side effects than semaglutide due to the additional pathway activation