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Nevertheless, this meta-analysis found that treatment with semaglutide was associated with increased occurrence of NAION. Broad Trial Review Shows Neutral Retinopathy Risk Following a comprehensive electronic search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials, the research team assessed ocular adverse events in 78 randomized clinical trials involving 73,640 adults receiving oral or injectable semaglutide