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Three alleles of the -GCS-HS subunit have been identified that differ by the number of GAG trinucleotide repeats in the 5' coding and non-coding region

Among oral systemic therapies, methotrexate and acitretin pose the highest hepatotoxic risks, necessitating frequent liver function tests and preventive measures

Men experienced approximately twice the magnitude of sexual effects compared to women, in both directions

Forty-eight weeks of close monitoring generates substantial safety data, and the results were encouraging enough to move the compound into Phase 3 without significant design changes to the safety monitoring framework