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Engeletin, a flavonoid from Smilax glabra , suppressed Toll-like receptor 4-NF-B signaling, reduced the expression of IL-1, IL-6, and TNF-, and inhibited macrophage polarization from the pro-inflammatory M1 phenotype
In response to neuronal activity, adaptive myelination regulates oligodendrocyte lineage dynamics via Neuregulin-ErbB and BDNF pathways, NMDA-receptor and GABAergic signaling, and activity-dependent ATP-LIF transduction, ultimately reshaping myelin sheath biogenesis and architecture (Bechler et al., 2018)
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