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2017 Dec 21;3(1):17040

9 These actions provide a compelling rationale for exploring incretin analogs not only as metabolic regulators but also as potential neuroprotective agents, positioning them as promising candidates for diseasemodifying interventions in Alzheimer's disease and related disorders

Musial C, Kuban-Jankowska A, Gorska-Ponikowska M

8.5 Geriatric Use JANUMET XR In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant disease or other drug therapy and the higher risk of lactic acidosis