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Diagram illustrating how lowdose methotrexate increases intracellular ATP/ADP, leading to enhanced extracellular efflux, resulting in conversion to adenosine via CD39 and CD73

However, the following symptoms that accompany a headache are cause for concern: a headache that does not go away a headache that gets worse sudden, intense head pain or pressure stiff neck fever nausea and vomiting dizziness or lightheadedness fainting vision changes confusion difficulty speaking weakness or droopiness on one side If youve been experiencing any of these symptoms in addition to your headaches, you should see a doctor immediately as it may indicate a more serious medical condition