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These compounds contain the trace element cobalt at the center of their structure, hence their name

Vaspin is a specific inhibitor of two kallikrein family members in KLK7 and KLK14 19,67 , and although vaspin does not inhibit KLK1 68 , KLK7 exhibits efficient kininogenase activity (releasing des-Arg9-bradykinin 69 ,), suggesting that vaspin may interact with the local kallikrein-kinin pathway to regulate the activity of thermogenic adipocytes (Fig

J Appl Physiol (1985)

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