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Through attenuation of chronic hypothalamicpituitaryadrenal (HPA) axis overactivation, adaptogens such as Withania somnifera can normalize thyrotropin-releasing hormone (TRH) and thyroid-stimulating hormone (TSH) signaling, thereby improving peripheral thyroid hormone bioavailability (186)
The MHRA encourages healthcare professionals and patients to report any suspected adverse reactions through the Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app), which is essential for detecting rare or previously unrecognised safety signals
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