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10 The induction of p70S6K1 activation in colon cancer cells is associated with resistance of IGF-1R inhibition since knockdown of p70S6K1 or inhibition of p70S6K1 activity enhances the cell sensitivity to IGF-1R inhibition

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Using the MelaFulKutis 3D pigmented skin model under UV and methylglyoxal exposure, the DEC-containing serum also reduced melanin deposition and downregulated microphthalmia-associated transcription factor (MITF) and TYR expression by 63.37% and 80.39%, respectively