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GLP-1 is also secreted from microglia (Kappe et al., 2012) and specific neurons of the nucleus tractus solitarius (NTS) (Cork et al., 2015), and convey vagal motor information to the pancreas (Parker et al., 2010

Currently there are over 100 agents being investigated in human trials.176 While each potential agent is beyond the scope of this review, we will focus on selected compounds anticipated for phase 3 trials, grouped by their mechanism of action and detailed in Table 4

The EMA is in the process of reviewing available data from clinical trials, post-marketing surveillance, and medical literature

GLP-1 receptor agonists are a class of medications that replicate the function of a naturally occurring hormone in the body: glucagon-like peptide-1