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In another study in which the animals were treated for 35 d with a daily dose of 300 mg/kg of Atlantic salmon skin gelatin hydrolysate, blood glucose levels were reduced to less than 200 mg/dl (111 mmol/l) during OGTT, insulin levels increased 3-fold, active GLP-1 levels increased 16-fold and DPP4 activity was reduced from 1155 to 826 % (lower than in normal rats) (Reference Hsieh, Wang and Hung47)

No systemic effects were consistently reported in these trials [6]

Based on this pharmacokinetic profile, administration of cagrilintide to participants with varying degrees of renal or hepatic impairment is expected to yield comparable exposure across dose levels and dosing frequencies, without compromising safety