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For the statistics of stress reporter assay data, R (3.3.2) (R Core Team, 2017) and nlme (Pinheiro et al., 2009) (nlme: Linear and Nonlinear Mixed Effects Model) was used to perform a linear mixed effect model for longitudinal data with the following call: lme [value time treatment_dose, random = time | plateID, correlation = corAR1 (form = 1 |plateID)]

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