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Cagrilintide has a plasma half-life of approximately 159 hours (~7 days) thanks to the acylated C20 fatty acid binding to albumin, which enables once-weekly dosing

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Whats worse, these drugs can trigger dry mouth by reducing saliva production and can induce ketosis, which is linked to a distinct fruity, sweet or metallic odor

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This multi-dimensional therapeutic potential is reshaping the positioning of GLP-1 drugs as comprehensive metabolic treatments rather than just glucose-lowering agents For instance, Novo Nordisks semaglutide is now marketed as Wegovy specifically for chronic weight management, while Eli Lillys tirzepatide has received FDA approval under the brand name Zepbound for obesity treatment, independent of diabetic status

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