Precision medicine approaches should enroll participants based on biological signatures rather than broad diagnostic categories, including glutathione status, lactate to pyruvate ratios, N acetyl aspartate, NRF2 related profiles, electron transport chain complex activity, and the presence of folate receptor alpha autoantibodies in cerebral folate deficiency
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Alternative approaches to oral cysteamine therapy have been proposed for cystinosis [82, 146, 151, 152]
Most orally delivered glutathione supplements first traverse the digestive system and are rapidly degraded by enzymatic breakdown, reducing the amount available for absorption