The early success of these drugs in combating what was considered to be an intractable public health concern has begun to reshape how society is framing obesity as a health issue, leading to ripple effects that are affecting how food is sold and consumed, insurance and workplace wellness policies, and importantly, public attitudes surrounding the veracity of framing obesity as a medical issue that can and should be treated
GLP-1 works beautifullystimulating insulin, suppressing glucagon, and slowing gastric emptyingbut it has a fatal flaw: It is destroyed by the enzyme DPP-4 within minutes of entering the bloodstream
Chen YA, Lu CY, Cheng WF, Kuo KT, Yu CW, Ho HN, et al
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