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M.et al (2010)

14.2 Obstructive Sleep Apnea Studies in Adults with Obesity Overview of Study 5 and Study 6 The efficacy of ZEPBOUND for moderate to severe obstructive sleep apnea (OSA) (apnea-hypopnea index [AHI] 15) in patients with obesity (BMI 30 kg/m2) was evaluated in a master protocol clinical trial (NCT05412004) that included two randomized, double-blind, placebo-controlled trials (Study 5 and Study 6) of 52 weeks duration

Tirzepatide, as a dual GIP/GLP-1 agonist, may produce slightly more pronounced effects because it typically produces greater weight loss (15% to 20% of body weight versus 10% to 15% for pure GLP-1 agonists) and more dramatic metabolic improvements