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Concurrently, high glucose suppressed the tumor suppressor TIF1, further amplifying Smad-mediated transcription and elevating the expression of pro-oncogenic genes, including the epithelialmesenchymal transition markers N-cadherin and vimentin, thereby collectively fostering CRC progression

The Timing Hypothesis This distinction gave rise to what is now called the timing hypothesis: the idea that the risks and benefits of HRT are critically dependent on when therapy begins relative to the onset of menopause [12]

As with GLP-1 medications for weight loss, Wegovy for heart disease should be paired with a balanced reduced calorie diet and increased physical activity