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Graphical Abstract Similar content being viewed by others Introduction Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, accounting for approximately 17.9 million deaths annually, representing around 32% of all global deaths [1]

Despite their therapeutic efficacy, the clinical application of GLP-1 receptor agonists is frequently associated with gastrointestinal complications, including nausea, vomiting, and diarrhea, with rare but serious adverse events such as pancreatitis and cholelithiasis being documented in clinical reports 10,11

Or, their high cost may limit accessibility

[1] [3] The injection bypasses the gastrointestinal tract entirely, making it particularly effective for patients with absorption problems such as pernicious anaemia or those who have undergone gastric surgery