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With the highest dose (2.4 mg), people have been shown to lose an average of 15% of their body weight in about 2 years

Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme

Animal studies have shown that even chronic daily exposure did not significantly desensitize GH release mechanisms [5] , though cycling is recommended as a precautionary measure