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BMJ 372:n71 Sterne JAC et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials

The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recommend SGLT2 inhibitors as a cornerstone of T2D treatment in adults ( SGLT2 inhibitors reduce the maximum reabsorption of glucose, thereby increasing urinary glucose excretion and lowering blood glucose concentration in an insulin-independent manner, as depicted in Figure 2 , according to previous studies ( Figure 2 We herein describe the progresses in treatment of pediatric T2D in a real-life setting