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Soon after this report, Hanahan and Weinberg also included reprogramming of energy metabolism as an emerging hallmark of cancer 14

Oral dosing is viable especially for GI-specific issues -- ulcers, IBD, NSAID-induced gut damage (Sikiric, 1999)

Effects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre

Immunogenicity: No Antibody Formation A critical safety consideration for any peptide therapy is immunogenicity, the potential to trigger immune system responses that could lead to allergic reactions, reduced efficacy through antibody neutralization, or autoimmune complications