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AGEs production in the hyperglycemic state and AGE-RAGE-induced increase in cytoplasmic ROS promote the production of mitochondrial superoxide and the development of diabetic microangiopathy in the condition of hyperglycemia

Many subjects with oral mucosal melanin hyperpigmentation, whether physiological or pathological in origin, are usually unaware of it so cannot give information about its duration or progression

g i ) Representative whole dorsal striatal images of NPY immunofluorescence from Trkb Penk-WT control ( g ), Trkb Penk-KO mutant injected at 3 M with Gsto2 -shRNA ( h ) or scrambled-shRNA in the striatum ( i ) and analysed at 15 W

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