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When appetite is reduced, and fat oxidation is increased, the body is able to burn more calories than it consumes, creating a negative energy balance, which is essential for weight loss

Dickson SL, Shirazi RH, Hansson C, Bergquist F, Nissbrandt H, Skibicka KP (2012)

General pathophysiology of astroglia

SH-SY5Y cell line is an immortalized cell culture system with obvious limitations for data interpretation, mainly due to the differences in cell cycle state and expression levels of neuronal markers that are observed in mature neurons