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Pharmacological interventions such as orlistat or GLP-1 receptor agonists may be considered for patients with BMI 30 kg/m who have not achieved adequate weight loss through lifestyle measures alone

doi: 10.1155/2020/2172740 61

Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology

Additionally, the TRPM8 gene, which responds to cold stimuli, has been linked to an increased risk of chronic migraine in individuals carrying the TRPM8 rs10166942 T allele (Ling et al., 2019)