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Results Lobeline alters SG dynamics by delaying SG dissolution post-hypoxia in immortalized and primary GBM cells A previous drug screen identified several FDA approved compounds that altered SG dynamics in immortalized U251 GBM cells exposed to hypoxia [18], with lobeline being the fourth highest candidate by Z -score to delay SG dissolution (Table 1)

When combined, this effect may be intensified, potentially increasing the risk of falls or accidents

By re-expressing GSTP1, increased detoxification, and reduced levels of oxidative stress could potentially contribute to reduced prostate cancer progression and even to an abrogation on evolution toward invasive and metastatic disease