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Resultant low systemic bioavailability: Consequently, even after oral administration of high doses, only a small fraction of curcumin reaches systemic circulation, limiting its ability to exert therapeutic effects at target tissues

As for dosage, niacinamide is often recommended at concentrations between 2%-5%, while kojic acid is used at concentrations between 1%-4%

They should not be combined with DPP-4 inhibitors