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NRF2 also cooperates with components of the transcriptional machinery (i.e., MED16) (Sekine et al, 2016), chromatin remodelers (i.e., BRG1) (Zhang et al, 2006) and chromatin-modifying enzymes (i.e., CBP) (Katoh et al, 2001) to drive target gene expression

In some cases, they increase, temporarily, with each increase in dosage

Obesity is currently a growing public health concern (134) and as weight loss improves many obesity-related complications (135), there is a great deal of interest in developing weight-loss drugs

Keep a tiny protein snack nearby, like yogurt, cottage cheese, turkey, egg, or a protein shake if tolerated