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Many community posts describe tirzepatides appetite effect as feeling smoother or longer-lasting across the weekly interval, whereas some report a more noticeable tapering with semaglutide toward the end of the week

If the pen is part of a pack, the quantity in the pack has been noted

It is advised to use a non-oral contraceptive method (instead of oral contraceptive) or, if using oral contraception- add a barrier method of contraception 4 weeks after initiation and 4 weeks after dose escalation