In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression
If inhibiting NAD+ synthesis has an adverse effect on 5-amino-1MQs muscle-enhancing effects, this would show that, indeed, the compound likely works through increasing NAD+ levels
For this reason, its been used to help enhance athletic performance, fight fatigue, and provide additional energy to get through hectic schedules
However, persistently high serum B12 levels warrant medical investigation, as they may indicate liver disease, kidney dysfunction, or haematological disorders rather than simple overconsumption