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Continuous microevolution accelerates disease progression during sequential episodes of infection

The SF3B1 mutation leads to aberrant alternative splicing of estrogen-related receptor gamma (ESRRG), resulting in ESRRGs stronger affinity for pituitary-specific positive transcription factor 1 and leading to lactotroph cells proliferation and PRL hypersecretion

From Days 3 to 8, the medium was switched to Knockout DMEM, 20% Knockout Serum Replacer, beta-mercaptoethanol (BME, 100 M), 1% Glutamax, non-essential amino acids, and 1% DMSO