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74 For example, MMP1, -3, and -13 cleave the N-terminus of MCP-1 and MCP-2 and transform their chemokine activity into an antagonistic activity and MMP1 and -3 degrade the active form of IL-1

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Therefore, conjugating CP to RGD's active sites may facilitate targeted delivery and enhance interference with tumor cell growth, although further experimental validation is needed to confirm these effects 170