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Description

Mechanistic data on GLP-1R/GIPR/GCGR tri-agonists The combination of GLP-1RA, GIPRA, and GCGRA in preclinical studies has demonstrated superior weight loss relative to liraglutide in mice with diet-induced obesity, attributed to decreased food intake and increased energy expenditure (Baggio & Drucker 2021)

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Figure 2A-B shows increased ROS in HO-treated IEC-6 cells, with SAC treatment reducing ROS levels compared to untreated cells

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