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Right now, many payers are taking a wait and see approach. Allen noted that some patients are seeing adverse effects when taking these drugs, such as vomiting and nausea, and are likely to regain weight after discontinuing the medications, which also leads to the hesitation

Epub 2022 Jun 27

10.1007/BF00714275

To help with explanations, a brief summary of the methionine cycle, transsulfuration pathway, and connections to the folate cycle and Betaine (GB) pathway is provided in the next paragraph, and a schematic representation in figure 1