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Hydration matters more on semaglutide because the gastrointestinal side effects, particularly vomiting and diarrhea, can cause significant fluid loss

Although this was an exploratory post hoc analysis, it is noteworthy that observed group differences suggested a trend toward bone loss, with consistently lower BMD and increased bone turnover at follow-up in the semaglutide + lifestyle counseling group compared to that in the lifestyle counseling alone

Journal of investigative dermatology

In direct comparison trials for diabetes (SURPASS-2 compared tirzepatide to semaglutide 1 mg), tirzepatide showed superior blood sugar control and greater weight loss