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Detailed transcriptomic and metabolomic comparisons led to the unexpected discovery that masculinized mutants ( mog-3(-), fem-3(-) gain-of-function ) partially mimic MID 21,56

In humans there is a 49-base-pair insert (a slightly longer insert in rodents) that produces a reading-frame shift during splicing, generating a mature isoform with a unique C-terminal peptide sequence that does not exist in the other IGF-1 variants

A particular class of peptides, called growth hormone secretagogues (GHS), specialize in muscle growth and fat loss

It turns out that this little chain of amino acids from heli monster venom turns on the same switches in a mammal's pancreas as GLP-1 does