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However, it should be noted that GLP-1RAs can enhance sympathetic activity, potentially increasing heart rate and blood pressure, despite their cardioprotective properties [66]

The preservation of full efficacy, despite lower potency, suggests that the compound effectively engages key activation-relevant residues within the receptor binding cavity, in agreement with predicted computational analyses

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Records documenting symptoms, diagnosis, treatment history, and the timing of medication use can help establish whether complications developed after exposure to semaglutide or tirzepatide medications