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Whether these effects are complementary, neutral, or potentially conflicting is not yet established through rigorous clinical trials

Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based quantitative methods are one of the most commonly used techniques, with the advantage of being able to efficiently separate and detect a variety of carnitine and its derivatives, including free carnitine, acylcarnitine, and their isomers and odd forms

Comparison with other glucose-lowering agents, comprising sulfonylurea, dipeptidyl peptidase 4 inhibitors (DPP4-I) and SGLT2i are summarized in Supplementary Material 5