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Understanding this natural degradation process has been fundamental to developing incretin-based medications that either resist breakdown or inhibit the DPP-4 enzyme, thereby prolonging the beneficial effects of these hormones in managing type 2 diabetes and, increasingly, obesity

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However, research, like a When there is already a pre-established metabolic disease, it becomes more of an uphill battle to reverse those abnormalities, especially if they have been established for a long time, Glickman says