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The DA-PLGA were administered intraperitoneally at doses of 10 mg or 20 mg per animal in a 6-hydroxydopamine mouse model of PD

Treatment with allopurinol results in the reduction in blood pressure in adolescents, 92 spontaneously hypertensive rats 93 and patients with CKD

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Chemical synthesis of these compounds would require not only the preparation of the (2 S ,3 S )- t -ES monoester but also subsequent multistep synthesis with protectiondeprotection steps 6 (Supplementary Fig