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Because of that, the amount actually used by the body may be limited

The predicted binding pose revealed that the compound establishes stabilizing interactions with a set of hydrophobic and aromatic residues lining the transmembrane binding cavity (Figure 4), including A200, L201, M204, L217, Y220, V229, and W297

Isotretinoin is a potent derivative of vitamin A, a retinoid, that's reserved almost exclusively for treating severe, recalcitrant nodular acne that hasn't responded to other treatments

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