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Combined presence of MAFLD and alcohol use showed an important synergistic detrimental effect in the younger population, which attenuated by increasing age category: for age-group A/B/C/D: adjusted Hazard Ratio (aHR) 2.34 (1.3-4.1), p=0.003, aHR 2.05 (1.3-3.2) p=0.001, aHR 1.35 (1.0-1.8) p=0.049 and aHR 1.24 (0.9-1.6) p=0.053, respectively (Table)

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Collective qualitative or quantitative results of these biomarkers may serve to predict potential morbidity and/or mortality of liver disease and failure, leading to appropriate triage of patients into those requiring emergency liver transplantation versus patients who are likely to have good clinical improvement with NAC therapy alone

In view of emerging antifibrotic therapies, there is an urgent need of non-invasive serum biomarkers to predict RC after LTX