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Preclinical cartilage evidence Kwon and Park 2015 in Annals of Clinical and Laboratory Science reported that intra-articular AOD-9604 plus hyaluronic acid in a rabbit knee osteoarthritis model improved cartilage histology and reduced lameness compared with hyaluronic acid alone

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TAKE YOUR FIRST STEP Prescription Medications Vitamin B12 can interact with certain medications, including folic acid tablets, and decrease their effectiveness

There are other large RCTs where similarly high doses of vitamin B 12 have been given together with other micronutrients.31 32 These studies found that the micronutrient mixture that included high doses of vitamin B 12 reduced the risk for small for gestational age (SGA) with no adverse effects