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Body composition in DIO mice with/without NNMT inhibition showing reduced WAT mass with preserved lean mass relative to diet-matched controls [1,3,4]

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Enhanced activity of IDO enzymes (IDO-1 and IDO-2) shifts tryptophan metabolism towards the kynurenine pathway, leading to increased concentrations of kynurenic acid (KYNA) within the CNS (216220)

B12 and Folate Diabetic patients who have used the commonly prescribed antidiabetic medication metformin long term may benefit from supplemental folate and B12, as the drug depletes levels of these two B vitamins