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Materials and Methods The authors used the Broad Institute's Connectivity Map (CMap) - a publicly available computer-based gene profiling tool

3 Pathophysiology of depression 3.1 Monoaminergic dysfunction Monoaminergic disruptions especially those related to serotonin (5-HT), norepinephrine (NE), and dopamine (DA), constitute a fundamental and classical mechanism in the pathophysiological framework of depression

The duration of the treatment can vary depending on the type of therapy being administered, often taking between 30 minutes to several hours

In healthy adults, these fluids are typically processed and excreted by the kidneys within four to six hours