Hormonal Recovery and System Reset While traditional SERM-based PCT (e.g., Clomid, Nolvadex) may not be necessary after HGH or IGF-1 LR3 alone, users should still support: Liver and metabolic health Insulin sensitivity restoration Endogenous IGF-1 balance Testosterone production (if steroids were included) Prolonged use of IGF-1 analogs may lead to negative feedback on GH/IGF axis and necessitate time off or tapering for hormonal normalization. Baxter, R
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Improved wound healing, reduced inflammation, reduced hepatic fat content, decreased infarct size following myocardial infarction or intracranial stroke, improved vascular function with decreased oxidative stress, improved endothelial dysfunction, and lowering of albuminuria have also been observed in pre-clinical studies [24]