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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

Acute activation of oxidative pentose phosphate pathway as first-line response to oxidative stress in human skin cells

Neutralizing oxidative stress caused by antibiotics can reduce their effectiveness

Remethylation Methionine synthase uses methylcobalamin and 5-methyl-THF to recycle homocysteine to methionine