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In high-fat-fed mice, the combined metabolic effect of incretins hesitates in more reduction of food intake and consequently more weight reduction (59)

The study followed strict protocols and considered subjects individually to ensure clinical translational efficacy

This suggests that specific concentrations of TGF- have permissive influences on satellite cells and it raises some concerns about the therapeutic window for inhibitors of this factor [47]

Mechanistically, GLP-1 signaling modulates immune and inflammatory pathways, regulates autophagy and pyroptosis, alleviates endoplasmic reticulum stress, and interacts with the gut microbiome